Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region

被引：72

作者：

Gomes-Gouvea, M. S. ^{[1
,2
]}

Soares, M. C. P. ^{[2
]}

Bensabath, G. ^{[2
]}

de Carvalho-Mello, I. M. V. G. ^{[1
,3
]}

Brito, E. M. F. ^{[2
]}

Souza, O. S. C. ^{[2
]}

Queiroz, A. T. L. ^{[4
]}

Carrilho, F. J. ^{[1
]}

Pinho, J. R. R. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Lab Trop Hepatol & Gastroenterol,Trop Med Inst, BR-05403000 Sao Paulo, Brazil

[2] Inst Evandro Chagas, Secao Hepatol, BR-66090000 Belem, Para, Brazil

[3] Inst Butantan, Lab Imunol Viral, BR-05503900 Sao Paulo, Brazil

[4] Univ Sao Paulo, Inst Biociencias, BR-05508900 Sao Paulo, Brazil

来源：

JOURNAL OF GENERAL VIROLOGY | 2009年 / 90卷

基金：

巴西圣保罗研究基金会;

关键词：

NORTHERN SOUTH-AMERICA; YUCPA INDIANS; SURFACE-ANTIGEN; SANTA-MARTA; INFECTION; BASIN; VENEZUELA; HDV; PREVALENCE;

D O I：

10.1099/vir.0.013615-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among fulminant hepatitis cases from the western Amazon Basin of Brazil were characterized in this study. HBV and HDV isolates were obtained from liver samples from 14 patients who developed fulminant hepatitis and died during 1978-1989. HBV DNA and HDV RNA were detected in all samples. Phylogenetic analyses of HDV sequences showed that they all clustered with previously characterized sequences of HDV genotype 3 (HDV-3). HBV genotypes F, A and D were found in 50.0, 28.6 and 21.4% of cases, respectively. These results confirm the predominance of HDV-3 in South America and its association with the severe form of hepatitis, and the finding of the co-infection of HDV-3 with different genotypes of HBV suggests that the association between HDV-3 and HBV-F is not necessarily causally related to a more severe clinical course of infection.

引用

页码：2638 / 2643

页数：6

共 32 条

[1]

BENSABATH G, 1983, REV I MED TROP, V25, P182

[2]

HEPATITIS-DELTA VIRUS-INFECTION AND LABREA HEPATITIS - PREVALENCE AND ROLE IN FULMINANT-HEPATITIS IN THE AMAZON BASIN [J].