Parenteral immunization of fish, Labeo rohita with Poly D, L-lactide-co-glycolic acid (PLGA) encapsulated antigen microparticles promotes innate and adaptive immune responses

被引：45

作者：

Behera, T. ^{[1
]}

Nanda, P. K. ^{[1
]}

Mohanty, C. ^{[2
]}

Mohapatra, D. ^{[1
]}

Swain, P. ^{[1
]}

Das, B. K. ^{[1
]}

Routray, P. ^{[1
]}

Mishra, B. K. ^{[1
]}

Sahoo, S. K. ^{[2
]}

机构：

[1] Cent Inst Freshwater Aquaculture, Fish Hlth Management Div, Bhubaneswar 751002, Orissa, India

[2] Inst Life Sci, Nanomed Lab, Bhubaneswar 751023, Orissa, India

来源：

FISH & SHELLFISH IMMUNOLOGY | 2010年 / 28卷 / 02期

关键词：

Aeromonas hydrophila; Immune response; Microparticles; Outer membrane proteins; PLGA; OUTER-MEMBRANE PROTEINS; BIODEGRADABLE MICROSPHERES; AEROMONAS-SALMONICIDA; ATLANTIC SALMON; RAINBOW-TROUT; VACCINE; RELEASE; DELIVERY; NANOPARTICLES; INJECTION;

D O I：

10.1016/j.fsi.2009.11.009

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Immunogenicity of different antigen preparations of outer membrane proteins (OMP) of Aeromonas hydrophila such as Poly D, L-lactide-co-glycolic acid (PLGA) microparticles, oil emulsion, neat OMP and bacterial whole cells were compared through intra-peritoneal injection in fish, Labeo rohita. Among these preparations, PLGA encapsulated antigen stimulated both innate and adaptive immune parameters and the immunogenicity exhibited by PLGA microparticles was significantly higher (p < 0.05) at both 21 and 42 days post-immunization suggesting that the above delivery system would be a novel antigen carrier for parenteral immunization in fish, Labeo rohita (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：320 / 325

页数：6

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