A role for P-glycoprotein in regulating cell death

被引：112

作者：

Johnstone, RW ^{[1
]}

Ruefli, AA ^{[1
]}

Tainton, KM ^{[1
]}

Smyth, MJ ^{[1
]}

机构：

[1] Austin & Repatriat Med Ctr, Austin Res Inst, Cellular Cytotox Lab, Heidelberg, Vic 3084, Australia

来源：

LEUKEMIA & LYMPHOMA | 2000年 / 38卷 / 1-2期

关键词：

P-glycoprotein; apoptosis; caspase; pore formation;

D O I：

10.3109/10428190009060314

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P-glycoprotein (P-gp) is an energy dependent drug pump responsible for multidrug resistance (MDR) in human cancers. While it is irrefutable that P-gp can efflux xenobiotics out of cells, the biological function of P-gp in multicellular organisms has yet to be firmly established. The question of what, if anything, P-gp does when nor effluxing drugs has been raised by recent reports indicating that P-gp may regulate apoptosis, chloride channel activity, cholesterol metabolism and immune cell function. There is now a lively debate regarding the possible role of P-gp in regulating cell differentiation, proliferation and survival.

引用

页码：1 / +

页数：12

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