Polycyclic diterpenoids from Euphorbia characias

被引:59
作者
Appendino, G
Belloro, E
Tron, GC
Jakupovic, J
Ballero, M
机构
[1] Dipartimento Sci & Tecnol Farm, I-10125 Turin, Italy
[2] Analyt AG, D-14473 Potsdam, Germany
[3] Dipartimento Sci Bot, I-09123 Cagliari, Italy
关键词
Euphorbia characias; diterpenes; ent-atisanes; ent-abietanolides; ent-pimaranes;
D O I
10.1016/S0367-326X(99)00134-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
In addition to widespread flavonoids, a collection of Euphorbia characias from Sardinia afforded 13 oxygenated diterpenoids of the atisane, abietane, pimarane, and kaurane type. Four of these compounds (1, 3a, 7a,b) are new. The accumulation of substantial amounts of biologically active diterpenoids of limited availability, like ent-atisanes endowed with anti-HIV activity and ent-abietanolides active on the central nervous system, makes E. characias an interesting source of lead compounds for biomedical research. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:134 / 142
页数:9
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