Rings, radicals, and regeneration: The early years of a bioorganic laboratory

被引：30

作者：

van der Donk, Wilfred A. ^{[1
]}

机构：

[1] Univ Illinois, Roger Adams Lab, Dept Chem, Urbana, IL 61801 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 26期

关键词：

D O I：

10.1021/jo0614240

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This Perspective provides an overview of the progress in two of the original programs in my research group focused on the biosynthesis of the antibiotics nisin, lacticin 481, fosfomycin, and bialaphos. The path from start-up funds to tenure and beyond offers insights into the opportunities realized and missed along the road.

引用

页码：9561 / 9571

页数：11

共 121 条

[1] Banerjee R, 1999, CHEM BIOCH B12
[2] STEREOSPECIFIC FREE-RADICAL ADDITION OF MENTHYL METHYLPHOSPHINATE TO ALKENES - EVIDENCE FOR INVERSION OF CONFIGURATION AT PHOSPHORUS
BENSCHOP, HP
PLATENBU.DH
[J]. JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1970, (17): : 1098 - &
[3] Engineering of a novel thioether bridge and role of modified residues in the lantibiotic pep5
Bierbaum, G
Szekat, C
Josten, M
Heidrich, C
Kempter, C
Jung, G
Sahl, HG
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1996, 62 (02) : 385 - 392
[4] Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736
Blodgett, JAV
Zhang, JK
Metcalf, WW
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (01) : 230 - 240
[5] Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic
Breukink, E
Wiedemann, I
van Kraaij, C
Kuipers, OP
Sahl, HG
de Kruijff, B
[J]. SCIENCE, 1999, 286 (5448) : 2361 - 2364
[6] Lipid II as a target for antibiotics
Breukink, E
de Kruijff, B
[J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (04) : 321 - 332
[7] FURTHER EVIDENCE FOR THE ROLE OF D-PI-P-PI BONDING IN RHODIUM-MEDIATED HYDROBORATIONS
BURGESS, K
VANDERDONK, WA
JARSTFER, MB
OHLMEYER, MJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (16) : 6139 - 6144
[8] TITANIUM-MEDIATED ADDITIONS OF BOROHYDRIDE TO ALKENES
BURGESS, K
VANDERDONK, WA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (15) : 6561 - 6569
[9] REACTIONS OF CATECHOLBORANE WITH WILKINSON CATALYST - IMPLICATIONS FOR TRANSITION METAL-CATALYZED HYDROBORATIONS OF ALKENES
BURGESS, K
VANDERDONK, WA
WESTCOTT, SA
MARDER, TB
BAKER, RT
CALABRESE, JC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (24) : 9350 - 9359
[10] Biosynthesis and mode of action of lantibiotics
Chatterjee, C
Paul, M
Xie, LL
van der Donk, WA
[J]. CHEMICAL REVIEWS, 2005, 105 (02) : 633 - 683

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