Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes

被引:182
作者
Hammer, MF
Redd, AJ
Wood, ET
Bonner, MR
Jarjanazi, H
Karafet, T
Santachiara-Benerecetti, S
Oppenheim, A
Jobling, MA
Jenkins, T
Ostrer, H
Bonné-Tamir, B
机构
[1] Univ Arizona, Lab Mol Systemat & Evolut, Tucson, AZ 85721 USA
[2] Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91120 Jerusalem, Israel
[3] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England
[4] Univ Witwatersrand, SAMIR, ZA-2000 Johannesburg, South Africa
[5] NYU, Med Ctr, Dept Pediat, New York, NY 10016 USA
[6] Sackler Sch Med, Dept Human Genet, IL-69978 Tel Aviv, Israel
基金
英国惠康基金;
关键词
D O I
10.1073/pnas.100115997
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Haplotypes constructed from Y-chromosome markers were used to trace the paternal origins of the Jewish Diaspora, A set of 18 biallelic polymorphisms was genotyped in 1,371 males from 29 populations, including 7 Jewish (Ashkenazi, Roman, North African, Kurdish, Near Eastern, Yemenite, and Ethiopian)and 16 non-Jewish groups from similar geographic locations. The Jewish populations were characterized by a diverse set of 13 haplotypes that were also present in non-Jewish populations from Africa, Asia, and Europe. A series of analyses was performed to address whether modern Jewish Y-chromosome diversity derives mainly from a common Middle Eastern source population or from admixture with neighboring non-Jewish populations during and after the Diaspora. Despite their long-term residence in different countries and isolation from one another, most Jewish populations were not significantly different from one another at the genetic level. Admixture estimates suggested low levels of European Y-chromosome gene flow into Ashkenazi and Roman Jewish communities. A multidimensional scaling plot placed six of the seven Jewish populations in a relatively tight cluster that was interspersed with Middle Eastern non-Jewish populations, including Palestinians and Syrians. Pairwise differentiation tests further indicated that these Jewish and Middle Eastern non-Jewish populations were not statistically different. The results support the hypothesis that the paternal gene pools of Jewish communities from Europe, North Africa, and the Middle East descended from a common Middle Eastern ancestral population, and suggest that most Jewish communities have remained relatively isolated from neighboring non-Jewish communities during and after the Diaspora.
引用
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页码:6769 / 6774
页数:6
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