Exosomes as Reconfigurable Therapeutic Systems

被引：228

作者：

Conlan, R. Steven ^{[1
]}

Pisano, Simone ^{[1
,2
]}

Oliveira, Marta I. ^{[3
]}

Ferrari, Mauro ^{[4
]}

Mendes Pinto, I. ^{[3
]}

机构：

[1] Swansea Univ, Med Sch, Swansea SA2 8PP, W Glam, Wales

[2] Univ Trieste, I-34127 Trieste, Italy

[3] Int Iberian Nanotechnol Lab, P-4715330 Braga, Portugal

[4] Houston Methodist Res Inst, Houston, TX 77030 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 07期

关键词：

CELLS SECRETE EXOSOMES; TRANSFERRIN RECEPTOR; DENDRITIC CELLS; TUMOR-ANTIGENS; BONE-MARROW; DELIVERY; MEDIATE; BRAIN; NANOVESICLES; ACTIVATION;

D O I：

10.1016/j.molmed.2017.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or 'exosomes'. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases.

引用

页码：636 / 650

页数：15

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