Advanced research on the microRNA mechanism in heart failure

被引：24

作者：

Deng, Jianying ^{[1
]}

Zhong, Qianjin ^{[1
]}

机构：

[1] Third Mil Med Univ, Inst Surg Res, Daping Hosp, 10 Changjiang Zhilu, Chongqing 400042, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2016年 / 220卷

基金：

中国国家自然科学基金;

关键词：

MicroRNA; Mechanism; Heart failure; BCL-2; FAMILY-MEMBER; CARDIAC-HYPERTROPHY; MYOCARDIAL-INFARCTION; RNA INTERFERENCE; DOWN-REGULATION; EXPRESSION; SURVIVAL; DYSFUNCTION; REPRESSION; CELLS;

D O I：

10.1016/j.ijcard.2016.06.185

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Heart failure is the end stage of most cardiac diseases and also an important cardiovascular disease. Ventricular remodeling, a complicated pathophysiological process involving multiple molecular pathways, is a crucial mechanism for the occurrence and development of heart failure. A microRNA (miRNA) is a highly conservative noncoding molecule containing 18-25 nucleotides. miRNA is different from other RNAs. It mainly serves as an endogenous gene-regulating factor, and is a member of the complex regulatory network. It induces gene repression of target transcripts by affecting mRNA at the post-transcriptional level Vasudevan et al. (2007). This study aimed at determining the mechanism of miRNA action in heart failure. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：61 / 64

页数：4

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