Gene x Environment Interactions in Type 2 Diabetes

被引：57

作者：

Franks, Paul W. ^{[1
]}

机构：

[1] Skane Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Hosp Malmo,CRC, S-20502 Malmo, Sweden

来源：

CURRENT DIABETES REPORTS | 2011年 / 11卷 / 06期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

Gene; Environment interaction; Type; 2; diabetes; GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; RECEPTOR-GAMMA COACTIVATOR-1; NON-HISPANIC WHITES; PHYSICAL-ACTIVITY; LIFE-STYLE; RISK-FACTORS; FTO GENE; POLYMORPHISM; MELLITUS;

D O I：

10.1007/s11892-011-0224-9

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene x environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene x environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging strategies that might enhance our ability to detect and exploit gene x environment interactions in complex disease traits.

引用

页码：552 / 561

页数：10

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