You are right too!

被引：68

作者：

Witztum, JL ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 08期

关键词：

D O I：

10.1172/JCI26130

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Macrophage scavenger receptors, such as CD36 and class A scavenger receptor (SR-A), have previously been thought to play a central role in foam cell formation and atherogenesis by mediating the uptake of oxidized LDL. In this issue of the JCI, Moore et al. report that Apoe(-/-) mice deficient in either CD36 or SR-A did not have less atherosclerosis at the level of the aortic valve than did wild-type Apoe(-/-) mice (see the related article beginning on page 2192). In contrast, similar studies by previous investigators found that deletion of these receptors decreased atherogenesis. The reasons for the different results are not known, but these data suggest that the role of these receptors in atherogenesis remains unresolved.

引用

页码：2072 / 2075

页数：4

共 25 条

[1] Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A [J].

Babaev, VR ;

Gleaves, LA ;

Carter, KJ ;

Suzuki, H ;

Kodama, T ;

Fazio, S ;

Linton, MF .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (12) :2593-2599

[2] Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosis [J].

Febbraio, M ;

Guy, E ;

Silverstein, RL .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (12) :2333-2338

[3] Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice [J].

Febbraio, M ;

Podrez, EA ;

Smith, JD ;

Hajjar, DP ;

Hazen, SL ;

Hoff, HF ;

Sharma, K ;

Silverstein, RL .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (08) :1049-1056

[4] Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes [J].

Freigang, S ;

Hörkkö, S ;

Miller, E ;

Witztum, JL ;

Palinski, W .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (12) :1972-1982

[5] Recent insights into the biology of macrophage scavenger receptors [J].

Greaves, DR ;

Gordon, S .

JOURNAL OF LIPID RESEARCH, 2005, 46 (01) :11-20

[6] LOW-DENSITY LIPOPROTEIN METABOLISM BY HUMAN MACROPHAGES ACTIVATED WITH LOW-DENSITY LIPOPROTEIN IMMUNE-COMPLEXES - A POSSIBLE MECHANISM OF FOAM CELL-FORMATION [J].

GRIFFITH, RL ;

VIRELLA, GT ;

STEVENSON, HC ;

LOPESVIRELLA, MF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (03) :1041-1059

[7] Lipoprotein receptors in the vascular wall [J].

Herz, J ;

Hui, DY .

CURRENT OPINION IN LIPIDOLOGY, 2004, 15 (02) :175-181

[8] CD36 is a sensor of diacylglycerides [J].

Hoebe, K ;

Georgel, P ;

Rutschmann, S ;

Du, X ;

Mudd, S ;

Crozat, K ;

Sovath, S ;

Shamel, L ;

Hartung, T ;

Zähringer, U ;

Beutler, B .

NATURE, 2005, 433 (7025) :523-527

[9] MONOCLONAL-ANTIBODIES AGAINST LDL FURTHER ENHANCE MACROPHAGE UPTAKE OF LDL AGGREGATES [J].

KHOO, JC ;

MILLER, E ;

PIO, F ;

STEINBERG, D ;

WITZTUM, JL .

ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (11) :1258-1266

[10] Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein [J].

Kruth, HS ;

Jones, NL ;

Huang, W ;

Zhao, B ;

Ishii, I ;

Chang, J ;

Combs, CA ;

Malide, D ;

Zhang, WY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (03) :2352-2360

← 1 2 3 →