Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis

被引：61

作者：

Brennan, Kathryn M. ^{[1
,2
]}

Galban-Horcajo, Francesc ^{[1
]}

Rinaldi, Simon ^{[1
,2
]}

O'Leary, Colin P. ^{[2
]}

Goodyear, Carl S. ^{[1
]}

Kalna, Gabriela ^{[3
]}

Arthur, Ariel ^{[1
]}

Elliot, Christina ^{[1
]}

Barnett, Sue ^{[1
]}

Linington, Christopher ^{[1
]}

Bennett, Jeffrey L. ^{[4
,5
]}

Owens, Gregory P. ^{[4
]}

Willison, Hugh J. ^{[1
,2
]}

机构：

[1] Univ Glasgow, Inst Infect Immun & Inflammat, Coll Med Vet & Life Sci, Glasgow Biomed Res Ctr, Glasgow G12 8TA, Lanark, Scotland

[2] So Gen Hosp, Dept Neurol, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland

[3] Univ Glasgow, Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[4] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO USA

[5] Univ Colorado, Dept Ophthalmol, Sch Med, Aurora, CO USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 238卷 / 1-2期

基金：

英国惠康基金;

关键词：

Multiple sclerosis; Oligoclonal bands; Cerebrospinal fluid; Lipids; Antibodies; CENTRAL-NERVOUS-SYSTEM; GUILLAIN-BARRE-SYNDROME; CEREBROSPINAL-FLUID; PANENCEPHALITIS BRAIN; MEASLES-VIRUS; ANTIGANGLIOSIDE ANTIBODIES; CLONAL EXPANSION; SPINAL-CORD; IN-VITRO; B-CELLS;

D O I：

10.1016/j.jneuroim.2011.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：87 / 95

页数：9

共 40 条

[1]

The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes [J].