Isoprostanes: an emerging role in vascular physiology and disease?

被引：45

作者：

Cracowski, JL ^{[1
]}

机构：

[1] Fac Med Grenoble, Pharmacol Lab, F-38700 La Tronche, France

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2004年 / 128卷 / 1-2期

关键词：

isoprostane; lipid peroxidation; vasoconstriction; atherosclerosis; hypertension; ischemia;

D O I：

10.1016/j.chemphyslip.2003.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among the isoprostanes, the 15-series F-2-isoprostanes and 15-E-2t-ISoP mediate vasoconstriction in different vascular beds and species. In addition, 15-F-2t-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. In clinical studies, 15-F-2t-IsoP levels are increased in some vascular disorders involving atherosclerosis, ischemia-reperfusion and inflammation. Whether the same effects observed in vitro are observed consistently in vivo at physiological concentrations and whether these effects contribute to pathological states in vivo is still debated. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：75 / 83

页数：9

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