There's more than one way to scale a synapse

被引：11

作者：

Aizenman, Carlos D. ^{[1
]}

Pratt, Kara G. ^{[1
]}

机构：

[1] Brown Univ, Dept Neurosci, Providence, RI 02912 USA

来源：

NEURON | 2008年 / 58卷 / 05期

关键词：

D O I：

10.1016/j.neuron.2008.05.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

TNF alpha has been proposed to underlie synaptic scaling, but the mechanism and functional significance of this remain unclear. In this issue of Neuron, Cingolani et al. demonstrate that TNFa can mediate scaling through the regulation of beta 3 integrins. Kaneko et al. show that TNF alpha-dependent synaptic scaling plays an important role in visual cortical plasticity.

引用

页码：651 / 653

页数：3

共 14 条

[1]

Control of synaptic strength by glial TNFα [J].

Beattie, EC ;

Stellwagen, D ;

Morishita, W ;

Bresnahan, JC ;

Ha, BK ;

Von Zastrow, M ;

Beattie, MS ;

Malenka, RC .

SCIENCE, 2002, 295 (5563) :2282-2285

[2]

Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse [J].

Chavis, P ;

Westbrook, G .

NATURE, 2001, 411 (6835) :317-321

[3]

Activity-dependent regulation of synaptic AMPA receptor composition and abundance by β3 integrins [J].

Cingolani, Lorenzo A. ;

Thalhammer, Agnes ;

Yu, Lily M. Y. ;

Catalano, Myriam ;

Ramos, Timothy ;

Colicos, Michael A. ;

Goda, Yukiko .

NEURON, 2008, 58 (05) :749-762

[4]

Critical periods for experience-dependent synaptic scaling in visual cortex [J].

Desai, NS ;

Cudmore, RH ;

Nelson, SB ;

Turrigiano, GG .

NATURE NEUROSCIENCE, 2002, 5 (08) :783-789

[5]

How monocular deprivation shifts ocular dominance in visual cortex of young mice [J].

Frenkel, MY ;

Bear, MF .

NEURON, 2004, 44 (06) :917-923

[6]

Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex [J].

Goel, Anubhuthi ;

Lee, Hey-Kyoung .

JOURNAL OF NEUROSCIENCE, 2007, 27 (25) :6692-6700

[7]

Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: Epidemiology, hypotheses, and animal models [J].

Hornig, M ;

Lipkin, WI .

MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS, 2001, 7 (03) :200-210

[8]

Rapid synaptic scaling induced by changes in postsynaptic firing [J].

Ibata, Keiji ;

Sun, Qian ;

Turrigiano, Gina G. .

NEURON, 2008, 57 (06) :819-826

[9]

Tumor necrosis factor-α mediates one component of competitive, experience-dependent plasticity in developing visual cortex [J].

Kaneko, Megumi ;

Stellwagen, David ;

Malenka, Robert C. ;

Stryker, Michael P. .

NEURON, 2008, 58 (05) :673-680

[10]

Synaptic scaling mediated by glial TNF-α [J].

Stellwagen, D ;

Malenka, RC .

NATURE, 2006, 440 (7087) :1054-1059

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