Total synthesis and structural confirmation of ent-galbanic acid and marneral

被引：12

作者：

Corbu, Andrei ^{[1
]}

Perez, Manuel ^{[1
]}

Aquino, Maurizio ^{[1
]}

Retailleau, Pascal ^{[1
]}

Arsenlyadis, Simeon ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 13期

关键词：

D O I：

10.1021/ol8010216

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

By capitalizing on a highly selective Claisen rearrangement, ent-galbanic acid 1 and (+)-marneral 2 have been synthesized. The relative configurations of (+)-1 and (+)-2 were unambiguously established by X-ray crystallographic analysis of the precursors 11a and 20, with the absolute configuration ensuing from their derivation from R-pulegone. In this way, the controversial issue of the configuration of galbanic acid was unequivocally settled.

引用

页码：2853 / 2856

页数：4

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