Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels

被引：69

作者：

Cao, Wei ^{[1
]}

Li, Xiao-Qiang ^{[1
]}

Wang, Xiang ^{[2
]}

Li, Tao ^{[3
]}

Chen, Xi ^{[1
]}

Liu, Shui-Bing ^{[1
]}

Mei, Qi-Bing ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacol, Xian 710032, Shaanxi, Peoples R China

[2] Xian Med Univ, Sch Basic Med, Dept Pathophysiol, Xian 710021, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Sch Med, Forens Dept, Xian 710061, Shaanxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 46卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Angelica sinensis; Polysaccharide; Anti-tumor; ACUTILOBA; FRACTIONATION; GROWTH; SUGARS; ROOT;

D O I：

10.1016/j.ijbiomac.2009.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this study, three acidic polysaccharides (APS-3a, APS-3b and APS-3c) were obtained from Angelica sinensis (Oliv.) Diels. They displayed different structural features and anti-tumor activities. APS-3b and APS-3c significantly inhibited the growth of 5780 tumors and increased the life spans of 5780 tumor-bearing mice, whereas APS-3a had no significant effect. Further experiments showed that APS-3b and APS-3c could cause a concentration-dependent proliferation of the splenocytes, up-regulate IFN-gamma, IL-2 and IL-6 mRNA expressions in splenocytes and stimulate the productions of NO and TNF-alpha in peritoneal macrophages. Taken together, the three acidic polysaccharides displayed different anti-tumor activities which were associated with their different structural characteristics. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：115 / 122

页数：8

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