Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

被引：166

作者：

Legrand, Nicolas ^{[2
]}

Ploss, Alexander ^{[3
]}

Balling, Rudi ^{[4
]}

Becker, Pablo D. ^{[4
]}

Borsotti, Chiara ^{[11
]}

Brezillon, Nicolas ^{[5
]}

Debarry, Jennifer ^{[4
]}

de Jong, Ype ^{[3
]}

Deng, Hongkui ^{[6
]}

Di Santo, James P. ^{[1
]}

Eisenbarth, Stephanie ^{[7
]}

Eynon, Elizabeth ^{[7
,8
]}

Flavell, Richard A. ^{[7
,8
]}

Guzman, Carlos A. ^{[4
]}

Huntington, Nicholas D. ^{[1
]}

Kremsdorf, Dina ^{[5
]}

Manns, Michael P. ^{[9
,10
]}

Manz, Markus G. ^{[11
]}

Mention, Jean-Jacques ^{[1
]}

Ott, Michael ^{[9
,10
]}

Rathinam, Chozhavendan ^{[7
]}

Rice, Charles M. ^{[3
]}

Rongvaux, Anthony ^{[7
]}

Stevens, Sean ^{[12
]}

Spits, Hergen ^{[2
]}

Strick-Marchand, Helene ^{[1
]}

Takizawa, Hitoshi ^{[11
]}

van Lent, Anja U. ^{[2
]}

Wang, Chengyan ^{[6
]}

Weijer, Kees ^{[2
]}

Willinger, Tim ^{[7
]}

Ziegler, Patrick ^{[11
]}

机构：

[1] Inst Pasteur, INSERM, U668, Cytokines & Lymphoid Dev Unit, F-75724 Paris, France

[2] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

[3] Rockefeller Univ, Lab Virol & Infect Dis, Ctr Study Hepatitis C, New York, NY 10065 USA

[4] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Lower Saxony, Germany

[5] Univ Paris 05, CHU Necker, INSERM, U845, F-75015 Paris, France

[6] Peking Univ, Coll Life Sci, Lab Stem Cell & Generat Biol, Beijing 100871, Peoples R China

[7] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[8] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

[9] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany

[10] Twincore Ctr Expt & Clin Infect Res, D-30625 Hannover, Germany

[11] Inst Res Biomed, CH-6500 Bellinzona, Switzerland

[12] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

来源：

CELL HOST & MICROBE | 2009年 / 6卷 / 01期

关键词：

IMMUNE-SYSTEM; MOUSE; CELLS; LIVER;

D O I：

10.1016/j.chom.2009.06.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

引用

页码：5 / 9

页数：5

共 15 条

[1] Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice [J].