Functionalization of carbon nanotubes with bovine serum albumin in homogeneous aqueous solution

被引:67
作者
Fu, KF
Huang, WJ
Lin, Y
Zhang, DH
Hanks, TW
Rao, AM
Sun, YP [1 ]
机构
[1] Clemson Univ, Dept Chem, Clemson, SC 29634 USA
[2] Clemson Univ, Ctr Adv Engn Fibers & Films, Howard L Hunter Chem Lab, Clemson, SC USA
[3] Furman Univ, Dept Chem, Greenville, SC 29613 USA
[4] Clemson Univ, Dept Phys & Astron, Kinard Lab, Clemson, SC 29634 USA
关键词
carbon nanotube; water-soluble; bioconjugates; protein; indirect functionalization; bovine serum;
D O I
10.1166/jnn.2002.135
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Single-walled (SWNTs) and multiple-walled (MWNTs) carbon nanotubes were solubilized via the esterification of nanotube-bound carboxylic acids by oligomeric polyethylene glycol compounds. The water-soluble samples were used as starting materials in reactions with bovine serum albumin (BSA) protein in ambient aqueous solutions. The reaction conditions were designed for thermodynamically favorable transformation from ester to amide linkages, yielding SWNT-BSA and MWNT-BSA conjugates. The results show that the use of soluble starting nanotube materials in an indirect functionalization method represents a valuable approach to the biomodification of carbon nanotubes.
引用
收藏
页码:457 / 461
页数:5
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