RETRACTED: The Microbiota in Inflammatory Bowel Disease in Different Age Groups (Retracted article. See vol. 32, pg. 312, 2014)

被引:45
作者
Cucchiara, Salvatore [1 ]
Iebba, Valerio [2 ]
Conte, Maria Pia [2 ]
Schippa, Serena [2 ]
机构
[1] Univ Roma La Sapienza, Pediat Gastroenterol & Liver Unit, Dept Pediat, IT-00161 Rome, Italy
[2] Univ Roma La Sapienza, Dept Publ Hlth Sci, Microbiol Unit, IT-00161 Rome, Italy
关键词
Microbiota; Inflammatory bowel disease; Biodiversity; 16S RIBOSOMAL-RNA; GRADIENT GEL-ELECTROPHORESIS; IN-SITU HYBRIDIZATION; ILEAL CROHNS-DISEASE; HUMAN FECAL SAMPLES; INTESTINAL MICROFLORA; GASTROINTESTINAL-TRACT; BACTERIAL COMMUNITIES; ULCERATIVE-COLITIS; PEDIATRIC-PATIENTS;
D O I
10.1159/000228558
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Many efforts were made in the past decades to assess the role of gut microbiota in inflammatory bowel diseases (IBD), leading to the hypothesis that an altered microbial composition, other than the presence of a specific pathogen, could be involved in the pathogenesis of the disease. On the other hand, existing differences in gut microbial community between distinct classes of age make sense of an increasing research in microbial shifts in IBD. Methods: Cultural, molecular, metabolomic and metagenomic approaches are trying to define the human gut microbiota in different age groups. Results and Conclusion: An increase in anaerobic bacteria (Bacteroides vulgatus, Streptococcus faecalis) was observed in adult IBD, whereas an increase in aerobic and facultative-anaerobic (Escherichia coli) was found in pediatric IBD. Overall higher bacterial cell counts were observed in IBD, jointly with a general loss of biodiversity and a preponderance of Bacteroidetes and a parallel decrease of Firmicutes phylum : a predominance of potential harmful members of Proteobacteria (E. coli) and low abundance of beneficial species (Faecalibacterium prausnitzii) was also reported in pediatric and adult age groups, respectively. Microbial community of elderly subjects contains a wider range of different species than those of children and adults, both in healthy and IBD status. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码:252 / 258
页数:7
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