Microbial/enzymatic synthesis of chiral intermediates for pharmaceuticals

被引：125

作者：

Patel, RN ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Proc Res & Dev, New Brunswick, NJ 08903 USA

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 2002年 / 31卷 / 06期

关键词：

biocatalysis; chiral intermediates; anticancer; antiviral; antihypertensive; anticholesterol; anti-Alzheimers; beta 3-receptors agonists; melatonin receptor agonists;

D O I：

10.1016/S0141-0229(02)00186-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates and fine chemicals are in high demand both from pharmaceutical and agrochemical industries for the preparation bulk drug substances and agricultural products. In this review article, microbial/enzymatic processes have been described for the synthesis of chiral intermediates for anticancer drugs, antiviral agents, beta3-receptor agonists, antihypertensive drugs, melatonin receptor agonists, anticholesterol drugs, and anti-Alzheimer's drugs. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：804 / 826

页数：23

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