Evaluation of somatostatin analogues for the detection and treatment of gastrinoma in a dog

被引:25
作者
Altschul, M
Simpson, KW
Dykes, NL
Mauldin, EA
Reubi, JC
Cummings, JF
机构
[1] CORNELL UNIV,COLL VET MED,DEPT CLIN SCI,ITHACA,NY 14853
[2] CORNELL UNIV,COLL VET MED,DEPT PATHOL,ITHACA,NY 14853
[3] CORNELL UNIV,COLL VET MED,DEPT ANAT,ITHACA,NY 14853
[4] UNIV BERN,INST PATHOL,DIV CELL BIOL & EXPT CANC RES,BERN,SWITZERLAND
关键词
D O I
10.1111/j.1748-5827.1997.tb03466.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 [兽医学];
摘要
Gastrinomas in dogs are difficult to diagnose, localise and treat, In humans, somatostatin analogues have improved localisation and treatment of gastrinomas, The somatostatin analogues pentetreotide and octreotide were evaluated for the detection and treatment of gastrinoma in a dog, (111)indium-pentetreotide scintigraphy revealed multiple areas of activity in the patient's mid-ventral abdomen which were consistent with masses in the pancreas and liver at laparotomy, Immunohistochemistry, electron microscopy and binding of I-125-[Tyr(3)]-octreotide in vitro confirmed the lesion as a gastrinoma which expressed somatostatin receptors, Octreotide at doses of 2, 4 and 8 mu g/kg caused transient decreases in circulating gastrin, Plasma somatostatin peaked at one hour after octreotide and was still detectable at four and six hours after administration of octreotide. Combination therapy with famotidine, omeprazole, sucralfate and increasing doses of octreotide allowed patient survival for 14 months.
引用
收藏
页码:286 / 291
页数:6
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