A model of immune regulation as a consequence of randomized lymphocyte division and death times

被引：131

作者：

Hawkins, E. D.

Turner, M. L.

Dowling, M. R.

van Gend, C.

Hodgkin, P. D.

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

[3] Univ Queensland, Sch Phys Sci, Brisbane, Qld 4072, Australia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 12期

关键词：

D O I：

10.1073/pnas.0700026104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The magnitude of an adaptive immune response is controlled by the interplay of lymphocyte quiescence, proliferation, and apoptosis. How lymphocytes integrate receptor-mediated signals influencing these cell fates is a fundamental question for understanding this complex system. We examined how lymphocytes interleave times to divide and die to develop a mathematical model of lymphocyte growth regulation. This model provides a powerful method for fitting and analyzing fluorescent division tracking data and reveals how summing receptor-mediated kinetic changes can modify the immune response progressively from rapid tolerance induction to strong immunity. An important consequence of our results is that intrinsic variability in otherwise identical cells, usually dismissed as noise, may have evolved to be an essential feature of immune regulation.

引用

页码：5032 / 5037

页数：6

共 43 条

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