Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis

被引：71

作者：

Bhowmick, Sourojit

Duseja, Rachna

Das, Sulagna

Appaiahgiri, Mohan Babu

Vrati, Sudhanshu

Basu, Anirban ^{[1
]}

机构：

[1] Natl Brain Res Ctr, Haryana, India

[2] Natl Inst Immunol, New Delhi, India

来源：

NEUROSCIENCE LETTERS | 2007年 / 414卷 / 01期

关键词：

Japanese encephalitis; IP-10; astrocytes; IFN-gamma;

D O I：

10.1016/j.neulet.2006.11.070

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Interferon-gamma inducible protein (IP-10 or CXCL-10) is a potent chemoattractant and has been suggested to enhance the severity of virus infection and neuronal injury. In order to assess functional importance of this chemokine in viral encephalitis, we have exploited an experimental model of Japanese encephalitis. We report for the first time that in Japanese encephalitis, astrocytes are the predominant source of IP-10. A progressive increase in IP-10 induction following viral infection is concomitant with the increase in IFN-gamma a known inducer of IP-10. However, this increase in IFN-gamma level is not sufficient to confer protection as animals eventually succumb to the infection. (c) 2007 Published by Elsevier Ireland Ltd.

引用

页码：45 / 50

页数：6

共 21 条

[1] Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis [J].