Strongyloidiasis - the most neglected of the neglected tropical diseases?

被引：398

作者：

Olsen, Annette ^{[1
]}

van Lieshout, Lisette ^{[3
]}

Marti, Hanspeter ^{[4
]}

Polderman, Ton ^{[3
]}

Polman, Katja ^{[5
]}

Steinmann, Peter ^{[6
,7
]}

Stothard, Russell ^{[8
]}

Thybo, Soren ^{[2
]}

Verweij, Jaco J. ^{[3
]}

Magnussen, Pascal ^{[1
]}

机构：

[1] Univ Copenhagen, DBL, Ctr Hlth Res & Dev, Copenhagen, Denmark

[2] Rigshosp, Dept Epidemiol, DK-2100 Copenhagen, Denmark

[3] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands

[4] Swiss Trop Inst, Dept Med & Diagnost Serv, CH-4002 Basel, Switzerland

[5] Inst Trop Med Prince Leopold, Dept Parasitol, B-2000 Antwerp, Belgium

[6] Swiss Trop Inst, Dept Publ Hlth & Epidemiol, CH-4002 Basel, Switzerland

[7] China CDC, Natl Inst Parasit Dis, Shanghai, Peoples R China

[8] Nat Hist Museum, Dept Zool, London SW7 5BD, England

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 103卷 / 10期

关键词：

Strongyloides stercoralis; Diagnosis; Morbidity; Treatment; Control; Neglected tropical disease; TRANSMITTED HELMINTH INFECTIONS; STERCORALIS; HOOKWORM; THERAPY; ANTIGEN;

D O I：

10.1016/j.trstmh.2009.02.013

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Soil-transmitted helminths of the genus Strongyloides (S. fuelleborni and the more prevalent S. stercoralis) are currently believed to infect an estimated 30-100 million people worldwide. The health consequences of S. stercoralis infections range from asymptomatic light infections to chronic symptomatic strongyloidiasis. Uncontrolled multiplication of the parasite (hyperinfection) and potentially Life-threatening dissemination of larvae to all internal organs is found among individuals with compromised immune system functions. This paper provides an overview of the current state of the art in relation to diagnostic methods for detecting the infection, the morbidity caused by the infection and the recommended treatment. It further discusses some of the reasons why this infection is so neglected and the consequence of this for the estimated global prevalence. The paper finally points to the gaps in our knowledge and future research needs related to this infection. As Strongyloides infections have the potential to develop into severe disease in certain population subgroups, untreated infections could cause serious problems in the community. Therefore, we need to carefully investigate this parasite in order to develop and implement effective control programmes. (c) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：967 / 972

页数：6

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