Survival of Ugandan infants with subtype A and D HIV-1 infection (HIVNET 012)

被引：6

作者：

Eshleman, SH

Guay, LA

Fleming, T

Mwatha, A

Mracna, M

Becker-Pergola, G

Musoke, P

Mmiro, F

Jackson, JB

机构：

[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[2] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[3] Makerere Univ, Dept Pediat, Kampala, Uganda

[4] Makerere Univ, Dept Obstet & Gynaecol, Kampala, Uganda

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2002年 / 31卷 / 03期

关键词：

HIV-1; Uganda; subtype; nevirapine; zidovudine; infant;

D O I：

10.1097/00126334-200211010-00009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virologic factors may influence survival of HIV-1-infected infants. We compared survival of Ugandan infants with subtype A and subtype D HIV-1 infection. This study was performed in the context of the Ugandan clinical trial HIVNET 012, which compared the efficacy of single-dose nevirapine (NVP) and short-course zidovudine (AZT) for prevention of HIV-1 mother-to-child transmission. HIV-1 sub-types were determined by phylogenetic analysis of HIV-1 protease and reverse transcriptase sequences from 32 women in the NVP arm and 54 women in the AZT arm of HIVNET 0 12 whose infants were HIV-1 infected by 6 to 8 weeks of age. We found no association between HIV-1 subtype (A vs. D) and infant survival in this cohort. Further studies are needed to evaluate whether HIV-1 subtype influences clinical outcome in pediatric HIV-1 infection.

引用

收藏

页码：327 / 330

页数：4

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