Modulation of autoimmune diseases by nitric oxide

被引：93

作者：

Singh, VK ^{[1
]}

Mehrotra, S

Narayan, P

Pandey, CM

Agarwal, SS

机构：

[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Immunol, Lab Mol Immunol, Lucknow, Uttar Pradesh, India

[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Biostat, Lucknow, Uttar Pradesh, India

[3] Sanjay Gandhi Postgrad Inst Med Sci, Dept Med Genet, Lucknow, Uttar Pradesh, India

来源：

IMMUNOLOGIC RESEARCH | 2000年 / 22卷 / 01期

关键词：

autoimmunity; immunomodulation; nitric oxide; Th1/Th2; cytokines;

D O I：

10.1385/IR:22:1:1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Nitric oxide (NO) is an intercellular messenger that performs a number of functions, including neurotransmission, vasodilatation, inhibition of platelet aggregation, and modulation of leukocyte adhesion. NO has recently been shown to act as a potent cytotoxic effector molecule as well as to play an important role in the pathogenesis of organ-specific autoimmunity. NO may also modulate the immune response by interfering with Th1/Th2 balance ire autoimmune diseases. This review will discuss the role of NO and nitric oxide synthase (NOS) in pathophysiologic and therapeutic implications in various autoimmune diseases with particular reference to T helper-1 (Th1) and T helper-2 (Th2) cytokines.

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页码：1 / 19

页数：19

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