Association of two variants in IL-1β and IL-1 receptor antagonist genes with multiple sclerosis

被引：56

作者：

Kantarci, OH

Atkinson, EJ

Hebrink, DD

McMurray, CT

Weinshenker, BG

机构：

[1] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA

[3] Mayo Clin & Mayo Fdn, Dept Pharmacol, Rochester, MN 55905 USA

[4] Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

[5] Mayo Clin & Mayo Fdn, Mol Neurosci Program, Rochester, MN 55905 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 106卷 / 1-2期

关键词：

genetics; interleukin-1; IL-1 receptor antagonist; multiple sclerosis; prognosis; susceptibility;

D O I：

10.1016/S0165-5728(00)00202-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the putative association of a C-->T polymorphism in exon-5 of IL-1 beta and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically-matched controls were analyzed. These was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1 beta and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030). (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：220 / 227

页数：8

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