Absence of toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells

被引：11

作者：

Groebner, Sabine

Schulz, Sebastian

Soldanova, Irena

Gunst, Dani S. J.

Waibel, Michaela

Wesselborg, Sebastian

Borgmann, Stefan

Autenrieth, Ingo B.

机构：

[1] Univ Tubingen, Inst Med Microbiol & Hyg, D-72076 Tubingen, Germany

[2] Univ Tubingen, Dept Internal Med 1, D-72076 Tubingen, Germany

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 01期

关键词：

D O I：

10.1128/IAI.00756-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In an initial period (<= 4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (> 4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.

引用

收藏

页码：512 / 517

页数：6

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