Searching for specificity in SH domains

被引:91
作者
Ladbury, JE
Arold, S
机构
[1] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
[2] Univ Oxford, Lab Mol Biophys, Oxford OX1 3QU, England
来源
CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 01期
关键词
D O I
10.1016/S1074-5521(00)00067-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Elucidating protein-protein interactions has been a central feature to understanding intracellular signal transduction. Many of the binding sites of the interacting proteins in these pathways are within highly sequentially homologous and structurally conserved domains. We challenge the dogma that mutual exclusivity in signalling is derived from a high level of specificity in these domains.
引用
收藏
页码:R3 / R8
页数:6
相关论文
共 29 条
[1]   RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef [J].
Arold, S ;
O'Brien, R ;
Franken, P ;
Strub, MP ;
Hoh, F ;
Dumas, C ;
Ladbury, JE .
BIOCHEMISTRY, 1998, 37 (42) :14683-14691
[2]   Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: A thermodynamic study [J].
Bradshaw, JM ;
Grucza, RA ;
Ladbury, JE ;
Waksman, G .
BIOCHEMISTRY, 1998, 37 (25) :9083-9090
[3]  
CHEN JK, 1995, ANGEW CHEM INT EDIT, V34, P953, DOI 10.1002/anie.199509531
[4]   Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides [J].
Chung, E ;
Henriques, D ;
Renzoni, D ;
Zvelebil, M ;
Bradshaw, JM ;
Waksman, G ;
Robinson, CV ;
Ladbury, JE .
STRUCTURE, 1998, 6 (09) :1141-1151
[5]   IDENTIFICATION OF A PROTEIN THAT BINDS TO THE SH3 REGION OF ABI AND IS SIMILAR TO BCR AND GAP-RHO [J].
CICCHETTI, P ;
MAYER, BJ ;
THIEL, G ;
BALTIMORE, D .
SCIENCE, 1992, 257 (5071) :803-806
[6]   MODULAR BINDING DOMAINS IN SIGNAL-TRANSDUCTION PROTEINS [J].
COHEN, GB ;
REN, RB ;
BALTIMORE, D .
CELL, 1995, 80 (02) :237-248
[7]   Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation [J].
Dibble, ARG ;
Hinderliter, AK ;
Sando, JJ ;
Biltonen, RL .
BIOPHYSICAL JOURNAL, 1996, 71 (04) :1877-1890
[8]   2 BINDING ORIENTATIONS FOR PEPTIDES TO THE SRC SH3 DOMAIN - DEVELOPMENT OF A GENERAL-MODEL FOR SH3-LIGAND INTERACTIONS [J].
FENG, SB ;
CHEN, JK ;
YU, HT ;
SIMON, JA ;
SCHREIBER, SL .
SCIENCE, 1994, 266 (5188) :1241-1247
[9]   NMR STRUCTURE OF THE N-TERMINAL SH3 DOMAIN OF GRB2 AND ITS COMPLEX WITH A PROLINE-RICH PEPTIDE FROM SOS [J].
GOUDREAU, N ;
CORNILLE, F ;
DUCHESNE, M ;
PARKER, F ;
TOCQUE, B ;
GARBAY, C ;
ROGUES, BP .
NATURE STRUCTURAL BIOLOGY, 1994, 1 (12) :898-907
[10]   Modular peptide recognition domains in eukaryotic signaling [J].
Kuriyan, J ;
Cowburn, D .
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1997, 26 :259-288