Searching for specificity in SH domains

被引：91

作者：

Ladbury, JE

Arold, S

机构：

[1] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

[2] Univ Oxford, Lab Mol Biophys, Oxford OX1 3QU, England

来源：

CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 01期

关键词：

D O I：

10.1016/S1074-5521(00)00067-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Elucidating protein-protein interactions has been a central feature to understanding intracellular signal transduction. Many of the binding sites of the interacting proteins in these pathways are within highly sequentially homologous and structurally conserved domains. We challenge the dogma that mutual exclusivity in signalling is derived from a high level of specificity in these domains.

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页码：R3 / R8

页数：6

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