Towards interbreed IBD fine mapping of the mh locus: Double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed

被引：74

作者：

Dunner, S

Charlier, C

Farnir, F

Brouwers, B

Canon, J

Georges, M

机构：

[1] UNIV LIEGE B43,FAC VET MED,DEPT GENET,B-4000 LIEGE,BELGIUM

[2] UNIV COMPLUTENSE MADRID,DEPT ANIM PROD,GENET LAB,E-28040 MADRID,SPAIN

来源：

MAMMALIAN GENOME | 1997年 / 8卷 / 06期

关键词：

D O I：

10.1007/s003359900462

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The Spanish ''Asturiana'' cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or ''culones''. We demonstrate by linkage analysis that this muscular hypertrophy involves the mh locus previously shown to cause double-muscling in the Belgian Blue cattle breed, pointing towards locus homogeneity of this trait across both breeds. Moreover, using a twopoint and multipoint maximum likelihood approach, we show that flanking microsatellite markers are in linkage disequilibrium with the mh locus in both breeds albeit with different alleles. Finally, we discuss how allelic homogeneity across breeds might be exploited to achieve efficient genetic fine-mapping of the mh locus.

引用

页码：430 / 435

页数：6

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