Advances in early kidney specification, development and patterning

被引：242

作者：

Dressler, Gregory R. ^{[1
]}

机构：

[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

DEVELOPMENT | 2009年 / 136卷 / 23期

基金：

美国国家卫生研究院;

关键词：

URETERAL BUD OUTGROWTH; RECEPTOR TYROSINE KINASE; STEM-CELLS CONTRIBUTE; MARROW-DERIVED CELLS; INTERMEDIATE MESODERM; BRANCHING MORPHOGENESIS; MAMMALIAN KIDNEY; GENE-EXPRESSION; METANEPHRIC MESENCHYME; RENAL DEVELOPMENT;

D O I：

10.1242/dev.034876

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The kidney is a model developmental system for understanding mesodermal patterning and organogenesis, a process that requires regional specification along multiple body axes, the proliferation and differentiation of progenitor cells, and integration with other tissues. Recent progress in the field has highlighted the essential roles of intrinsic nuclear factors and secreted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning. How these developments influence and advance our understanding of kidney development is discussed.

引用

页码：3863 / 3874

页数：12

共 120 条

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