Arc/Arg3.1: Linking gene expression to synaptic plasticity and memory

被引：204

作者：

Tzingounis, Anastassios V. ^{[1
]}

Nicoll, Roger A.

机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

来源：

NEURON | 2006年 / 52卷 / 03期

关键词：

D O I：

10.1016/j.neuron.2006.10.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.

引用

页码：403 / 407

页数：5

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