mGLuR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination

被引：339

作者：

Ichise, T

Kano, M

Hashimoto, K

Yanagihara, D

Nakao, K

Shigemoto, R

Katsuki, M

Aiba, A ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Ctr Med Expt, Lab DNA Biol & Embryo Engn, Tokyo 1088639, Japan

[2] Kanazawa Univ, CREST, Kanazawa, Ishikawa 9208640, Japan

[3] Kanazawa Univ, Sch Med, Dept Physiol, Kanazawa, Ishikawa 9208640, Japan

[4] Toyohashi Univ Technol, Toyohashi, Aichi 4418580, Japan

[5] RIKEN, Brain Sci Inst, Wako, Saitama 3510198, Japan

[6] Natl Inst Physiol Sci, Lab Cerebral Struct, Okazaki, Aichi 4448585, Japan

来源：

SCIENCE | 2000年 / 288卷 / 5472期

关键词：

D O I：

10.1126/science.288.5472.1832

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the Cerebellum, We introduced the mGluR1 alpha transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter, mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.

引用

页码：1832 / 1835

页数：4

共 29 条

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