Refeeding increases hepatic insulin-like growth factor-I (IGF-I) gene expression and plasma IGF-I concentration in fasted chicks

被引：21

作者：

Kita, K ^{[1
]}

Hangsanet, K ^{[1
]}

Shibata, T ^{[1
]}

Conlon, MA ^{[1
]}

Sasaki, T ^{[1
]}

Saito, N ^{[1
]}

Okumura, J ^{[1
]}

机构：

[1] Nagoya Univ, Sch Agr Sci, Chikusa Ku, Nagoya, Aichi 46401, Japan

来源：

BRITISH POULTRY SCIENCE | 1998年 / 39卷 / 05期

关键词：

D O I：

10.1080/00071669888566

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

1. We examined the influence of refeeding after 2 d of fasting on plasma insulin-like growth factor-I (IGF-I) concentration and hepatic IGF-I gene expression in chickens at 6 weeks of age. 2. Hepatic IGF-I mRNA was measured by ribonuclease protection assay and plasma IGF-I concentration was determined by radioimmunoassay. 3. Plasma IGF-I concentration decreased following fasting, increased to the level of fed controls after 2 h of refeeding but then fell back to the level of fasted chickens after 6 h of refeeding. 4. Fasting reduced hepatic IGF-I mRNA concentrations to less than half of those in the fed controls. Refeeding increased IGF-I mRNA sharply at 2 h after refeeding, but by 6 h after refeeding they had taller back again to levels significantly lower than at 2 h. 5. A significant correlation between plasma IGF-I concentration and hepatic IGF-I gene expression was found, suggesting that when chicks are refed after 2 d of fasting, the short-term increase in plasma IGF-I concentration may be partly regulated by the alteration in hepatic IGF-I mRNA.

引用

页码：679 / 682

页数：4

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