Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus

被引：193

作者：

Hayden, MK

Rezai, K

Hayes, RA

Lolans, K

Quinn, JP

Weinstein, RA

机构：

[1] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[2] Stroger Cook Cty Hosp, Chicago, IL USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 10期

关键词：

D O I：

10.1128/JCM.43.10.5285-5287.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.

引用

页码：5285 / 5287

页数：3

共 14 条

[1] Bactericidal activities of two daptomycin regimens against clinical strains of glycopeptide intermediate-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and methicillin-resistant Staphylococcus aureus isolates in an in vitro pharmacodynamic model with simulated endocardial vegetations [J].