Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease

被引：182

作者：

Hardie, D. Grahame ^{[1
]}

机构：

[1] Univ Dundee, Div Mol Physiol, Coll Life Sci, Dundee DD1 5EH, Scotland

来源：

FEBS LETTERS | 2008年 / 582卷 / 01期

基金：

英国惠康基金;

关键词：

AMP-activated protein kinase; metabolic syndrome; diabetes; metformin; thiazolidinedione; ventricular pre-excitation;

D O I：

10.1016/j.febslet.2007.11.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity, type 2 diabetes and the metabolic syndrome are disorders of energy balance, which the AMP-activated protein kinase (AMPK) regulates both at the cellular and whole body levels. AMPK switches cells from an anabolic state where nutrients are taken up and stored, to a catabolic state where they are oxidized. Drugs that activate AMPK indirectly (metformin and thiazolidinediones) are now the mainstay of treatment for type 2 diabetes, but more direct AMPK activators may have fewer side effects. However, activating mutations in AMPK can cause heart disease, and it will be important to look for adverse effects in the heart. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：81 / 89

页数：9

共 86 条

[1]

AKMAN HO, 2007, PED RES

[2] Role of hypothalamic adenosine 5′-monophosphate activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia [J].

Alquier, Thierry ;

Kawashima, Junji ;

Tsuji, Youki ;

Kahn, Barbara B. .

ENDOCRINOLOGY, 2007, 148 (03) :1367-1375

[3] Components of a calmodulin-dependent protein kinase cascade -: Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase β [J].

Anderson, KA ;

Means, RL ;

Huang, QH ;

Kemp, BE ;

Goldstein, EG ;

Selbert, MA ;

Edelman, AM ;

Fremeau, RT ;

Means, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (48) :31880-31889

[4] AMP-activated protein kinase plays a role in the control of food intake [J].

Andersson, U ;

Filipsson, K ;

Abbott, CR ;

Woods, A ;

Smith, K ;

Bloom, SR ;

Carling, D ;

Small, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12005-12008

[5] The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C-elegans [J].

Apfeld, J ;

O'Connor, G ;

McDonagh, T ;

DiStefano, PS ;

Curtis, R .

GENES & DEVELOPMENT, 2004, 18 (24) :3004-3009

[6] AMP-activated protein kinase in the heart - Role during health and disease [J].

Arad, Michael ;

Seidman, Christine E. ;

Seidman, J. G. .

CIRCULATION RESEARCH, 2007, 100 (04) :474-488

[7] EFFECT OF METFORMIN ON GLUCOSE-METABOLISM IN THE SPLANCHNIC BED [J].

BAILEY, CJ ;

WILCOCK, C ;

DAY, C .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (04) :1009-1013

[8]

Barnes K, 2002, J CELL SCI, V115, P2433

[9] The structure of a domain common to archaebacteria and the homocystinuria disease protein [J].

Bateman, A .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (01) :12-13

[10] Effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats [J].

Bergeron, R ;

Previs, SF ;

Cline, GW ;

Perret, P ;

Russell, RR ;

Young, LH ;

Shulman, GI .

DIABETES, 2001, 50 (05) :1076-1082

← 1 2 3 4 5 6 7 8 9 →