Tumour-cell fusion as a source of myeloid traits in cancer

被引:121
作者
Pawelek, JM
机构
[1] Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Yale Canc Ctr, New Haven, CT 06520 USA
关键词
D O I
10.1016/S1470-2045(05)70466-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Malignant cells express molecular pathways that are also expressed by myeloid cells. Such behaviour is associated with loss of homotypic adhesion between cells, changes in the cellular matrix, induction of angiogenesis, motility, chemotaxis, and several immune-signalling pathways. The overlap between malignant cells and myeloid cells could be explained by one mechanism: fusion of myeloid cells and tumour cells, as noted in animal studies and in two patients with renal-cell carcinoma who underwent bone-marrow transplantation. An overlapping trait in these cells is their glycosylation patterns: hybrids have high expression of N-terminal glycosylation and beta 1,6-branched Oligosaccharides. In macrophages and cancer cells, these structures have a role in motility and systemic migration; in cancer, they are associated with metastasis and poor prognosis. In addition to myeloid traits, fusion might contribute to aneuploidy and plasticity in cancer. Understanding metastatic cells as myeloid-tumour hybrids suggests new strategies for diagnosis, treatment, and prevention of malignant disease.
引用
收藏
页码:988 / 993
页数:6
相关论文
共 50 条
  • [1] Aggarwal A, 2005, CANCER RES, V65, P186
  • [2] Aichel O., 1911, VORTR GE AUFS TZE BE, P92
  • [3] Banerjee SS, 2000, HISTOPATHOLOGY, V36, P387
  • [4] Spontaneously formed tumorigenic hybrids of Meth A sarcoma cells and macrophages in vivo
    Busund, LTR
    Killie, MK
    Bartnes, K
    Seljelid, R
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2003, 106 (02) : 153 - 159
  • [5] Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient
    Chakraborty, A
    Lazova, R
    Davies, S
    Bäckvall, H
    Ponten, F
    Brash, D
    Pawelek, J
    [J]. BONE MARROW TRANSPLANTATION, 2004, 34 (02) : 183 - 186
  • [6] Chakraborty AK, 2001, CELL GROWTH DIFFER, V12, P623
  • [7] Human monocyte X mouse melanoma fusion hybrids express human gene
    Chakraborty, AK
    Sousa, JD
    Espreafico, EM
    Pawelek, JM
    [J]. GENE, 2001, 275 (01) : 103 - 106
  • [8] Chakraborty AK, 2000, CANCER RES, V60, P2512
  • [9] Dissemination and growth of cancer cells in metastatic sites
    Chambers, AF
    Groom, AC
    MacDonald, IC
    [J]. NATURE REVIEWS CANCER, 2002, 2 (08) : 563 - 572
  • [10] Clark W H Jr, 1977, Adv Cancer Res, V24, P267, DOI 10.1016/S0065-230X(08)61017-9