5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination

被引：54

作者：

Clasen, P. C. ^{[1
]}

Wells, T. T. ^{[1
]}

Knopik, V. S. ^{[2
]}

McGeary, J. E. ^{[3
,4
]}

Beevers, C. G. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[2] Brown Univ, Rhode Isl Hosp, Dept Psychiat & Human Behav, Div Behav Genet, Providence, RI 02903 USA

[3] Brown Univ, Providence Vet Affairs Med Ctr, Providence, RI 02912 USA

[4] Brown Univ, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA

来源：

GENES BRAIN AND BEHAVIOR | 2011年 / 10卷 / 07期

关键词：

BDNF Val66Met; biological sensitivity; genes; 5-HTTLPR; life stress; rumination; SEROTONIN TRANSPORTER GENE; DEPRESSIVE SYMPTOMS; ASSOCIATION; ANXIETY; ADOLESCENTS; HYPOTHESIS; DYSPHORIA; AMYGDALA; ALLELES; EVENTS;

D O I：

10.1111/j.1601-183X.2011.00715.x

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

This study examined whether polymorphisms in the serotonin transporter (SLC6A4, 5-HTTLPR) and brain-derived neurotropic factor (BDNF Val66Met, rs6265) genes moderate the relationship between life stress and rumination. Participants were a large homogenous group of healthy, unmedicated, never depressed individuals with few current symptoms of depression (N = 273). Results indicate that individuals with two short (S) alleles of the 5-HTTLPR polymorphism or two Met alleles of the BDNF Val66Met polymorphism ruminate more under conditions of life stress, compared to the other genotypes. Moreover, the accumulation of risk alleles (i.e. S and Met alleles) across genes is associated with significantly greater rumination in the context of life stress. These results suggest that both 5-HTTLPR and BDNF Val66Met moderate the relationship between life stress and rumination. These findings support the notion that variation in these genes is associated with biological sensitivity to the negative effects of stress.

引用

页码：740 / 746

页数：7

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