Rhombenone: Farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean

被引：16

作者：

Kwon, BM

Lee, SH

Kim, KS

Lee, LR

Lee, UC

Hong, SH

Bok, SH

机构：

[1] EWHA WOMANS UNIV,COLL PHARM,SEOUL,SOUTH KOREA

[2] KOREA RES INST GINSENG & TOBACCO,TAEJON,SOUTH KOREA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(97)00139-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rhombenone, a new dammarane analogue containing an 25-oxo, which inhibits farnesyl protein transferase (FPTase), was isolated from the leaves of Hedera rhombea Bean. Additional related dammaranes were also evaluated for FPTase inhibition. (C) 1997 Elsevier Science Ltd.

引用

页码：971 / 974

页数：4

共 12 条

[1]

CHUNG BS, 1990, HYANGYAK DAESAJUN, P436

[2]

DERPYL DV, 1992, ANTIBIOTICS, V45, P1802

[3] RAS C-TERMINAL PROCESSING ENZYMES - MINIREVIEW NEW DRUG TARGETS [J].

GIBBS, JB .

CELL, 1991, 65 (01) :1-4

[4] PROTEIN FARNESYLTRANSFERASE - MEASUREMENT OF ENZYMATIC-ACTIVITY IN 96-WELL FORMAT USING TOPCOUNT MICROPLATE SCINTILLATION-COUNTING TECHNOLOGY [J].

HARWOOD, HJ .

ANALYTICAL BIOCHEMISTRY, 1995, 226 (02) :268-278

[5]

HISHAM S, 1996, MAG RES CHEM, V34, P146

[6] BENZODIAZEPINE PEPTIDOMIMETICS - POTENT INHIBITORS OF RAS FARNESYLATION IN ANIMAL-CELLS [J].

JAMES, GL ;

GOLDSTEIN, JL ;

BROWN, MS ;

RAWSON, TE ;

SOMERS, TC ;

MCDOWELL, RS ;

CROWLEY, CW ;

LUCAS, BK ;

LEVINSON, AD ;

MARSTERS, JC .

SCIENCE, 1993, 260 (5116) :1937-1942

[7]

KIZU H, 1985, CHEM PHARM BULL, V33, P1400

[8] SELECTIVE-INHIBITION OF RAS-DEPENDENT TRANSFORMATION BY A FARNESYLTRANSFERASE INHIBITOR [J].

KOHL, NE ;

MOSSER, SD ;

DESOLMS, SJ ;

GIULIANI, EA ;

POMPLIANO, DL ;

GRAHAM, SL ;

SMITH, RL ;

SCOLNICK, EM ;

OLIFF, A ;

GIBBS, JB .

SCIENCE, 1993, 260 (5116) :1934-1937

[9] INHIBITION OF FARNESYLTRANSFERASE INDUCES REGRESSION OF MAMMARY AND SALIVARY CARCINOMAS IN RAS TRANSGENIC MICE [J].

KOHL, NE ;

OMER, CA ;

CONNER, MW ;

ANTHONY, NJ ;

DAVIDE, JP ;

DESOLMS, SJ ;

GIULIANI, EA ;

GOMEZ, RP ;

GRAHAM, SL ;

HAMILTON, K ;

HANDT, LK ;

HARTMAN, GD ;

KOBLAN, KS ;

KRAL, AM ;

MILLER, PJ ;

MOSSER, SD ;

ONEILL, TJ ;

RANDS, E ;

SCHABER, MD ;

GIBBS, JB ;

OLIFF, A .

NATURE MEDICINE, 1995, 1 (08) :792-797

[10]

Lee Ihn Rhan, 1993, Archives of Pharmacal Research (Seoul), V16, P331, DOI 10.1007/BF02977526

← 1 2 →