Highly enantioselective aminoacylase-catalyzed transesterification of secondary alcohols

被引：39

作者：

Bakker, M ^{[1
]}

Spruijt, AS ^{[1
]}

van Rantwijk, F ^{[1
]}

Sheldon, RA ^{[1
]}

机构：

[1] Delft Univ Technol, Organ Chem & Catalysis Lab, NL-2628 BL Delft, Netherlands

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(00)00118-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The aminoacylase (N-acyl-L-amino acid amidohydrolase; E.C. 3.5.1.14) from Aspergillus melleus, a readily available inexpensive enzyme, catalyzes the transesterification of a wide range of chiral secondary arylalkanols with essentially absolute stereoselectivity (E > 500). Moreover, the productivities obtained with 1-phenylethanol, 1-phenylpropanol, 1-(1-naphthyl)ethanol and 1-(2-naphthyl)ethanol were substantially higher than those in the corresponding lipase-catalyzed transesterifications. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1801 / 1808

页数：8

共 24 条

[1]

Andersch P, 1997, METHOD ENZYMOL, V286, P406

[2]

BAKKER M, IN PRESS J MOL CAT B

[3]

BOMMARIUS AS, 1992, ANN NY ACAD SCI, V672, P126

[4] GENERAL-ASPECTS AND OPTIMIZATION OF ENANTIOSELECTIVE BIOCATALYSIS IN ORGANIC-SOLVENTS - THE USE OF LIPASES [J].