Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation

被引：71

作者：

Cascante, M

Centelles, JJ

Veech, RL

Lee, WNP

Boros, LG

机构：

[1] Univ Calif Los Angeles, Sch Med, Harbor UCLA Res & Educ Inst, Torrance, CA 90502 USA

[2] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Dept Biochem & Mol Biol, E-08028 Barcelona, Catalonia, Spain

[3] NIAAA, NIH, Rockville, MD 20852 USA

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2000年 / 36卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1207/S15327914NC3602_2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-1) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that transketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of patients with cancer.

引用

页码：150 / 154

页数：5

共 32 条

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THIAMIN STATUS OF EARLY CANCER-PATIENTS WITH PARTICULAR REFERENCE TO THOSE WITH BREAST AND BRONCHIAL CARCINOMAS [J].