Vitamins B2 and B6 and Genetic Polymorphisms Related to One-Carbon Metabolism as Risk Factors for Gastric Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

被引：37

作者：

Eussen, Simone J. P. M. ^{[1
]}

Vollset, Stein Emil ^{[1
,3
]}

Hustad, Steinar ^{[1
,2
]}

Midttun, Oivind ^{[1
,4
]}

Meyer, Klaus ^{[1
]}

Fredriksen, Ase ^{[1
]}

Ueland, Per Magne ^{[1
]}

Jenab, Mazda ^{[5
]}

Slimani, Nadia ^{[5
]}

Ferrari, Pietro ^{[5
]}

Agudo, Antonio ^{[6
]}

Sala, Nuria ^{[7
]}

Capella, Gabriel ^{[7
]}

Del Giudice, Giuseppe ^{[8
]}

Palli, Domenico ^{[9
]}

Boeing, Heiner ^{[10
]}

Weikert, Cornelia ^{[10
]}

Bueno-de-Mesquita, H. Bas ^{[11
]}

Buechner, Frederike L. ^{[11
]}

Carneiro, Fatima ^{[12
,13
]}

Berrino, Franco ^{[14
]}

Vineis, Paolo ^{[15
,16
]}

Tumino, Rosario ^{[17
]}

Panico, Salvatore ^{[18
]}

Berglund, Goran ^{[19
]}

Manjer, Jonas ^{[20
]}

Stenling, Roger ^{[21
]}

Hallmans, Goeran ^{[22
]}

Martinez, Carmen ^{[23
,24
]}

Arrizola, Larraitz ^{[24
,25
]}

Barricarte, Aurelio ^{[24
,26
]}

Navarro, Carmen ^{[24
,27
]}

Rodriguez, Laudina ^{[28
,29
]}

Bingham, Sheila ^{[30
,31
]}

Linseisen, Jakob ^{[32
,33
]}

Kaaks, Rudolf ^{[32
]}

Overvad, Kim ^{[34
]}

Tjonneland, Anne ^{[35
]}

Peeters, Petra H. M. ^{[15
,36
]}

Numans, Mattijs E. ^{[36
]}

Clavel-Chapelon, Francoise ^{[37
,38
]}

Boutron-Ruault, Marie-Christine ^{[37
,38
]}

Morois, Sophie ^{[37
,38
]}

Trichopoulou, Antonia ^{[39
]}

Lund, Eiliv ^{[40
]}

Plebani, Mario ^{[41
]}

Riboli, Elio ^{[15
]}

Gonzalez, Carlos A. ^{[6
]}

机构：

[1] Univ Bergen, Dept Pharmacol, Inst Med, LOCUS Homocysteine & Related Vitamins, Bergen, Norway

[2] Haukeland Hosp, Hormone Lab, Bergen, Norway

[3] Norwegian Inst Publ Hlth, Oslo, Norway

[4] Bevital AS, Bergen, Norway

[5] IARC WHO, Lyon, France

[6] IDIBELL Catalan Inst Oncol, Unit Nutr Environm & Canc, Girona, Catalonia, Spain

[7] Transit Lab Res ICO, Barcelona, Spain

[8] Novartis Vaccines & Diagnost, Res Ctr, Siena, Italy

[9] Sci Inst Tuscany, Ist Studio & Prevenz Oncol, Mol & Nutr Epidemiol Unit, Florence, Italy

[10] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[11] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[12] Univ Porto, Inst Pathol & Mol Immunol, P-4100 Oporto, Portugal

[13] Med Fac HS Joao, Oporto, Portugal

[14] Ist Nazl Tumori, Fondaz IRCCS, Etiol Epidemiol & Prevent Unit, I-20133 Milan, Italy

[15] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

[16] Univ Turin, Dept Biomed Sci, Turin, Italy

[17] Canc Registry Azienda Osped Civile MP Arezzo, Ragusa, Italy

[18] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[19] Lund Univ, Dept Med, S-22100 Lund, Sweden

[20] Univ Hosp, Dept Surg, Malmo, Sweden

[21] Umea Univ, Dept Biomed Sci, Umea, Sweden

[22] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[23] Andalusian Sch Publ Hlth, Granada, Spain

[24] CIBER Epidemiol & Salud Publ, Madrid, Spain

[25] Dep Publ Hlth Gipuzkoa, San Sebastian, Spain

[26] Publ Hlth Inst Navarra, Pamplona, Spain

[27] Hlth Council Murcia, Dept Epidemiol, Murcia, Spain

[28] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[29] Consejeria Salud & Serv Sanitarios Asturias, Direcc Gen Salud Publ, Asturias, Spain

[30] MRC Dunn Human Nutr Unit, Cambridge, England

[31] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge, England

[32] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[33] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany

[34] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[35] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[36] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[37] Inst Natl Sante & Rech Med, ERI 20, EA 4045, Villejuif, France

[38] Inst Gustave Roussy, Villejuif, France

[39] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[40] Univ Tromso, Inst Community Med, Tromso, Norway

[41] Univ Padua, Azienda Osped, Dept Lab Med, I-35100 Padua, Italy

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2010年 / 19卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

HELICOBACTER-PYLORI INFECTION; UPPER GASTROINTESTINAL-TRACT; STOMACH-CANCER; METHYLENETETRAHYDROFOLATE-REDUCTASE; NUTRIENT INTAKE; HOMOCYSTEINE METABOLISM; MTHFR POLYMORPHISMS; ATROPHIC GASTRITIS; PERNICIOUS-ANEMIA; FOLATE-DEFICIENCY;

D O I：

10.1158/1055-9965.EPI-08-1096

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin 132 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for CC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P-trend) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, <0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with CC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and CC risk, which is borderline significant, and a significant inverse association between vitamin B6 and CC risk. Cancer Epidemiol Biomarkers Prev; 19(1); 28-38. (C)2010 AACR.

引用

页码：28 / 38

页数：11

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