Direct liquid chromatographic enantiomer separation of new fluoroquinolones including gemifloxacin

被引：64

作者：

Lee, W ^{[1
]}

Hong, CY ^{[1
]}

机构：

[1] LG Chem Ltd, Yusung Gu, Taejon 305380, South Korea

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 879卷 / 02期

关键词：

enantiomer separation; gemifloxacin; fluoroquinolones;

D O I：

10.1016/S0021-9673(00)00322-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomers of gemifloxacin mesylate(formerly LB20304a), a new fluoroquinolone compound with potent in vitro and in vivo antibacterial profile were resolved on a commercially available Crownpak CR chiral stationary phase (CSP). All of the fluoroquinolones, including gemifloxacin used in this study, were well enantioseperated on Crownpak CR(+) column. These results are the first reported for the direct separation of the enantiomers of quinolones on chiral crown ether coated Crownpak CR CSP. The behavior of chromatographic parameters by the change of mobile phase additives for the resolution of gemifloxacin was investigated. Also, the effect of structural change of gemifloxacin on chiral recognition was described. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：113 / 120

页数：8

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