Expedited publication - Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user

被引：82

作者：

Kish, SJ

Furukawa, Y

Ang, L

Vorce, SP

Kalasinsky, KS

机构：

[1] Ctr Addict & Mental Hlth, Human Neurochem Pathol Sect, Toronto, ON M5T 1R8, Canada

[2] Ctr Addict & Mental Hlth, Movement Disorder Res Lab, Toronto, ON M5T 1R8, Canada

[3] Sunnybrook Hosp, Dept Pathol Neuropathol, Toronto, ON, Canada

[4] Off Armed Forces Med Examiner, Div Forens Toxicol, Washington, DC USA

来源：

NEUROLOGY | 2000年 / 55卷 / 02期

关键词：

D O I：

10.1212/WNL.55.2.294

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors found that striatal levels of serotonin and those of its metabolite 5-hydroxyindoleacetic acid were severely depleted by 50 to 80% in brain of a chronic user of methylenedioxymethamphetamine (MDMA) whereas concentrations of dopamine were within the normal control range. Our data suggest that MDMA exposure in the human can cause decreased tissue stores of serotonin and therefore some of the behavioral effects of this drug of abuse could be caused by massive release and depletion of brain serotonin.

引用

页码：294 / 296

页数：3

共 7 条

[1] Memory impairment in abstinent MDMA ("Ecstasy") users [J].