Transcriptional regulation of gene expression by metalloproteins

被引：9

作者：

Aono, S ^{[1
]}

Nakajima, H ^{[1
]}

机构：

[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Tatsunokuchi, Ishikawa 9231292, Japan

来源：

PROGRESS IN REACTION KINETICS AND MECHANISM | 2000年 / 25卷 / 01期

关键词：

transcriptional regulator; DNA-binding protein; iron-sulfur cluster; iron-sulfur protein; heme protein; CO sensor; O-2; sensor; sensor protein; oxidative stress; nitric oxide; superoxide; FNR; SoxR; CooA;

D O I：

10.3184/007967400103165128

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

FNR and SoxR are transcriptional regulators containing an iron-sulfur cluster. The iron-sulfur cluster in FNR acts as an oxygen sensor by reacting with oxygen. The structural change of the iron-sulfur cluster takes place when FNR senses oxygen, which regulates the transcriptional regulator activity of FNR through the change of the quaternary structure. SoxR contains the [2Fe-2S] cluster that regulates the transcriptional activator activity of SoxR. Only the oxidized SoxR containing the [2Fe-2S](2+) cluster is active as the transcriptional activator. CooA is a transcriptional activator containing a protoheme that acts as a CO sensor. CO is a physiological effector of CooA and regulates the transcriptional activator activity of CooA. In this review, the biochemical and biophysical properties of FNR, SoxR, and CooA are described. Prog React Kinet Mech 25: 65-107 (C) 2000 Science Reviews.

引用

页码：65 / 107

页数：43

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