Quantitative trait loci analysis affecting contextual conditioning in mice

被引：111

作者：

Caldarone, B

Saavedra, C

Tartaglia, K

Wehner, JM

Dudek, BC

Flaherty, L

机构：

[1] SUNY ALBANY,DEPT PSYCHOL,ALBANY,NY 12222

[2] SUNY ALBANY,DEPT BIOMED SCI,ALBANY,NY 12222

[3] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,MOL GENET PROGRAM,ALBANY,NY 12201

[4] UNIV COLORADO,INST BEHAV GENET,BOULDER,CO 80309

来源：

NATURE GENETICS | 1997年 / 17卷 / 03期

关键词：

D O I：

10.1038/ng1197-335

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (led scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with rod scores ranging from 1.8 to 2.7.

引用

页码：335 / 337

页数：3

共 16 条

[1] REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE [J].