Human herpesvirus 6B infection of the large intestine of patients with diarrhea

被引：24

作者：

Amo, K

Tanaka-Taya, K

Inagi, R

Miyagawa, H

Miyoshi, H

Okusu, I

Sashihara, J

Hara, J

Nakayama, M

Yamanishi, K

Okada, S

机构：

[1] Osaka Univ, Dept Pediat, Grad Sch Med, Osaka 5650871, Japan

[2] Osaka Univ, Dept Microbiol, Grad Sch Med, Osaka 5650871, Japan

[3] Osaka Med Ctr, Dept Pediat, Osaka, Japan

[4] Res Inst Maternal & Child Hlth, Osaka, Japan

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 36卷 / 01期

关键词：

D O I：

10.1086/345464

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.

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页码：120 / 123

页数：4

相关论文

共 11 条

[1] GENOMIC POLYMORPHISM, GROWTH-PROPERTIES, AND IMMUNOLOGICAL VARIATIONS IN HUMAN HERPESVIRUS-6 ISOLATES [J].

ABLASHI, DV ;

BALACHANDRAN, N ;

JOSEPHS, SF ;

HUNG, CL ;

KRUEGER, GRF ;

KRAMARSKY, B ;

SALAHUDDIN, SZ ;

GALLO, RC .

VIROLOGY, 1991, 184 (02) :545-552

[2] ESTABLISHMENT OF TITRATION SYSTEM FOR HUMAN HERPESVIRUS-6 AND EVALUATION OF NEUTRALIZING ANTIBODY-RESPONSE TO THE VIRUS [J].

ASADA, H ;

YALCIN, S ;

BALACHANDRA, K ;

HIGASHI, K ;

YAMANISHI, K .

JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (10) :2204-2207

[3] SEVERITY OF HUMAN HERPESVIRUS-6 VIREMIA AND CLINICAL FINDINGS IN INFANTS WITH EXANTHEM-SUBITUM [J].

ASANO, Y ;

NAKASHIMA, T ;

YOSHIKAWA, T ;

SUGA, S ;

YAZAKI, T .

JOURNAL OF PEDIATRICS, 1991, 118 (06) :891-895

[4] Human herpesvirus-6 infection in children with cancer [J].

Michálek, J ;

Horváth, R ;

Benedík, J ;

Hrstková, H .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1999, 16 (05) :423-430

[5] Cytomegalovirus retinitis after transplantation of positively selected CD34+ cells from HLA-mismatched donors [J].

Miyoshi, H ;

Tanaka-Taya, K ;

Nagae, Y ;

Aono, T ;

Fujisaki, H ;

Matsuda, Y ;

Osugi, Y ;

Hara, J ;

Mori, Y ;

Sunagawa, T ;

Tano, Y ;

Okada, S ;

Yamanishi, K .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1998, 17 (04) :345-348

[6]

Ruther U, 1998, HEPATO-GASTROENTEROL, V45, P691

[7] ISOLATION OF A NEW VIRUS, HBLV, IN PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERS [J].

SALAHUDDIN, SZ ;

ABLASHI, DV ;

MARKHAM, PD ;

JOSEPHS, SF ;

STURZENEGGER, S ;

KAPLAN, M ;

HALLIGAN, G ;

BIBERFELD, P ;

WONGSTAAL, F ;

KRAMARSKY, B ;

GALLO, RC .

SCIENCE, 1986, 234 (4776) :596-601

[8] DIFFUSE INTESTINAL ULCERATION AFTER MARROW TRANSPLANTATION - A CLINICOPATHOLOGICAL STUDY OF 13 PATIENTS [J].

SPENCER, GD ;

SHULMAN, HM ;

MYERSON, D ;

THOMAS, ED ;

MCDONALD, GB .

HUMAN PATHOLOGY, 1986, 17 (06) :621-633

[9]

TanakaTaya K, 1996, J MED VIROL, V48, P88, DOI 10.1002/(SICI)1096-9071(199601)48:1<88::AID-JMV14>3.0.CO

[10]

2-2