Catalytic enantioselective synthesis of key intermediates for triazole antifungal agents

被引：50

作者：

Suzuki, M ^{[1
]}

Kato, N ^{[1
]}

Kanai, M ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 13期

关键词：

D O I：

10.1021/ol050398+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short-step synthesis of versatile chiral building blocks for triazole antifungal agents such as ZD0870 and Sch45450 was developed via catalytic enantioselective cyanosilylation of electron-deficient ketones as the key step. High enantioselectivity was produced using a catalyst prepared from Gd(HMDS)(3) and ligand 5 in a 2:3 ratio. This new catalyst preparation method was superior to the previous method using Gd((OPr)-Pr-i)(3) as a metal source. A rationale for the difference is proposed on the basis of structural studies of the catalyst complexes using ESI-MS.

引用

页码：2527 / 2530

页数：4

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