Laminin inhibits amyloid-beta-peptide fibrillation

被引：56

作者：

Bronfman, FC ^{[1
]}

Garrido, J ^{[1
]}

Alvarez, A ^{[1
]}

Morgan, C ^{[1
]}

Inestrosa, NC ^{[1
]}

机构：

[1] PONTIFICIA UNIV CATOLICA CHILE,FAC CIENCIAS BIOL,DEPT BIOL CELULAR & MOL,SANTIAGO,CHILE

来源：

NEUROSCIENCE LETTERS | 1996年 / 218卷 / 03期

关键词：

laminin; amyloid-beta-peptide; Alzheimer's disease;

D O I：

10.1016/S0304-3940(96)13147-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-beta-peptide (A beta) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/A beta protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit AP fibrillogenesis in vivo, specifically at the level of cerebral blood vessels.

引用

页码：201 / 203

页数：3

共 23 条

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