The survival kinases Akt and Pim as potential pharmacological targets

被引：359

作者：

Amaravadi, R ^{[1
]}

Thompson, CB ^{[1
]}

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol & Med, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 10期

关键词：

D O I：

10.1172/JCI26273

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.

引用

页码：2618 / 2624

页数：7

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