Selection of genomic target RNAs by iterative screening

被引：2

作者：

Brunel, C

Ehresmann, B

Ehresmann, C

McKeown, M

机构：

[1] CNRS, Inst Biol Mol & Cellulaire, UPR 9002, F-67084 Strasbourg, France

[2] Salk Inst, Mol Biol & Virol Lab, San Diego, CA 92186 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0968-0896(01)00029-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A growing number of proteins are known to exert their regulatory or biological functions via RNA binding. In some cases genetic interactions allow us to infer candidate targets for RNA directed regulation, but in many other cases identification of potential regulatory targets is problematic. We have developed an in vitro biochemical screen, SETIS (SElection of < < genomic > > Target RNAs by Iterative Screening) that allows screening of a major portion of the genome for identification of potential targets for RNA binding proteins. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2533 / 2541

页数：9

共 28 条

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